ANTIHYPERLIPIDEMIC EFFECT OF ETHANOLIC SEED EXTRACT OF CANAVALIA ENSIFORMIS ( L) IN HIGH FAT DIET -STREPTOZOTOCIN INDUCED RATS
By: Anitha, K
.
Contributor(s): Puthalapattu, Ravikumar Yashoda.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(1).Description: 99-102p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:
It was investigated to enlighten the phytochemical screening and
antihyperlipidemic
activity
of seeds of
Canavalia ensiformis (L.)
in High
fat diet Streptozotocin
-induced
diabetic rats.
Method
s:
The
e
thanolic seed extract of
Canavalia ensiformis
(EECE) at a dose of 40
0 mg
/kg and 200 mg/kg was administered to diabetic r
ats.
Simvastatin (
4 mg/kg) is used as
a standard
drug.
Result
s:
The statistics
were
assessed by using one way ANOVA followed by Dunnet’s multiple comparison tests. To unfold the mechanism we
studied
all the biochemical parameters like
Total cholesterol (T
C), Triglycerides
(TG),
high
-density
lipoproteins
(HDL
),
low
-density
lipoproteins
(LDL
) and histopathological examination of Liver tissue section. The ethanolic extracts of seeds of
Canavalia ensiformis
showed significant reduce
of
the
level
of cholesterol
, triglycerides, LDL, VLDL and
a significant
increase in the serum level of HDL at 40
0 mg
/kg rather than 200 mg/kg.
Conclusio
n:
Further the characterization and isolation of the constituents could be done to know the exact mechanism of hyperlipidemic ac
tiv
ity.
Statistical analysis of this screening method conforms
that the proposed method is
appropriate
and it can be useful, gives the basic idea to the
researcher who is working in
an
area
like Antihyperlipidemic activity.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020943 |
Objective:
It was investigated to enlighten the phytochemical screening and
antihyperlipidemic
activity
of seeds of
Canavalia ensiformis (L.)
in High
fat diet Streptozotocin
-induced
diabetic rats.
Method
s:
The
e
thanolic seed extract of
Canavalia ensiformis
(EECE) at a dose of 40
0 mg
/kg and 200 mg/kg was administered to diabetic r
ats.
Simvastatin (
4 mg/kg) is used as
a standard
drug.
Result
s:
The statistics
were
assessed by using one way ANOVA followed by Dunnet’s multiple comparison tests. To unfold the mechanism we
studied
all the biochemical parameters like
Total cholesterol (T
C), Triglycerides
(TG),
high
-density
lipoproteins
(HDL
),
low
-density
lipoproteins
(LDL
) and histopathological examination of Liver tissue section. The ethanolic extracts of seeds of
Canavalia ensiformis
showed significant reduce
of
the
level
of cholesterol
, triglycerides, LDL, VLDL and
a significant
increase in the serum level of HDL at 40
0 mg
/kg rather than 200 mg/kg.
Conclusio
n:
Further the characterization and isolation of the constituents could be done to know the exact mechanism of hyperlipidemic ac
tiv
ity.
Statistical analysis of this screening method conforms
that the proposed method is
appropriate
and it can be useful, gives the basic idea to the
researcher who is working in
an
area
like Antihyperlipidemic activity.
Click on an image to view it in the image viewer
There are no comments for this item.